• What are the common side effects associated with my treatment options?
  • How does the overall safety profile of my treatment options compare?
  • Is there one treatment option that you think has an overall better safety profile than the others?
  • Do some CLL treatment options have less treatment discontinuation rates over others?
  • What is tumor lysis syndrome and is it associated with any CLL treatments?

  • Are there any cardiovascular (heart)-related side effects associated with these treatments including atrial fibrillation and ventricular arrhythmia (sudden cardiac death)?
  • Are there studies that demonstrate differences in heart health outcomes between these treatments?
  • How often should I monitor my heart health while undergoing treatment, and what tests are recommended?
  • Are there any known effects on blood pressure associated with these treatments?
  • Will my treatment plan need to be adjusted if my heart health is affected?
  • Is there one treatment that you think has less risk to my heart health than the others?

  • What specific gastrointestinal (stomach) side effects are common with these treatments?
  • How should I treat any stomach side effects while on these treatments?
  • Will the stomach side effects be temporary (transient) or last a while?
  • Will my treatment plan need to be adjusted if my stomach side effects last a long time or worsen?
  • Is there one treatment that you think causes fewer stomach side effects than the others?
  • Is there one treatment that is associated with more diarrhea?

  • How common are headaches in these treatments?
  • Will headaches get better, worse, or stay the same over time with these treatments?
  • Are there specific warning signs I should look out for in my headaches?
  • How can I manage headaches while on treatment?
  • Is there a specific dosage of the treatment that may be more or less likely to cause headaches?
  • Will my treatment plan need to be adjusted if my headaches last a long time or worsen?
  • Is there one treatment that you think causes fewer headaches than the others?

  • How common is fatigue (extreme tiredness) with these treatments?
  • Will fatigue get better, worse, or stay the same over time on these treatments?
  • How can I manage fatigue while on treatment?
  • Is there one treatment that you think causes less fatigue than the others?

  • How does long-term use of these treatments affect my overall quality of life?
  • Do you have any information on these treatments’ side effects in the real world?

  • Which laboratory tests should be completed while I am taking this treatment?
  • Will this treatment affect my antibody (immunoglobulin) levels (IgG, IgA, IgM)?
  • Should my absolute neutrophil count be monitored?
  • Are there any laboratory markers that may predict infection risk?
  • Are there any laboratory markers that may predict bleeding risk?
  • Are there any laboratory markers that may predict heart-related side effects?
  • If my laboratory values change, how might that affect my dose or treatment plan?

  • Will this treatment affect my immune system over time?
  • Does this treatment increase my risk of serious infections?
  • What types of infections are most common with this treatment?
  • How does infection risk change over time with certain treatments?
  • Are there differences in infection rates among BTK inhibitors?
  • Will this treatment affect my antibody levels and should these levels be monitored while on treatment?
  • Are there vaccines I should receive before starting therapy?
  • If I develop recurrent infections, are there any interventions available?