Pharmacokinetics (PK) describes what the body does to a medicine. Examples include how quickly the body processes the medicine and how quickly the body eliminates the medicine.
Pharmacodynamics (PD) describes what the medicine does to the body. Examples include how strongly a medicine blocks a protein and how different dose levels affect the body.
PK and PD work as a team to answer the question of how much of a medicine (dose) and how often it is taken (dosing schedule) will have the desired effect on the body.
Many CLL treatments, called BTK inhibitors, block a protein called Bruton’s tyrosine kinase (BTK), which helps CLL cells to survive. “BTK occupancy” (also called BTK coverage, inhibition, or engagement) refers to how much of the BTK protein gets blocked.
How Can PK, PD, and BTK Occupancy Affect Treatment Choices?
